Review





Similar Products

lair1 overexpression cassette  (Shanghai Genechem Ltd)
86
Shanghai Genechem Ltd lair1 overexpression cassette
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
Lair1 Overexpression Cassette, supplied by Shanghai Genechem Ltd, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/lair1 overexpression cassette/product/Shanghai Genechem Ltd
Average 86 stars, based on 1 article reviews
lair1 overexpression cassette - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
29 mer scrambled shrna cassette  (OriGene)
94
OriGene 29 mer scrambled shrna cassette
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
29 Mer Scrambled Shrna Cassette, supplied by OriGene, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/29 mer scrambled shrna cassette/product/OriGene
Average 94 stars, based on 1 article reviews
29 mer scrambled shrna cassette - by Bioz Stars, 2026-06
94/100 stars
  Buy from Supplier
shrna cassettes  (Merck & Co)
86
Merck & Co shrna cassettes
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
Shrna Cassettes, supplied by Merck & Co, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/shrna cassettes/product/Merck & Co
Average 86 stars, based on 1 article reviews
shrna cassettes - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
u6 promoter shrna cassettes  (Twist Bioscience)
86
Twist Bioscience u6 promoter shrna cassettes
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
U6 Promoter Shrna Cassettes, supplied by Twist Bioscience, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/u6 promoter shrna cassettes/product/Twist Bioscience
Average 86 stars, based on 1 article reviews
u6 promoter shrna cassettes - by Bioz Stars, 2026-06
86/100 stars
  Buy from Supplier
non effective 29 mer scrambled shrna cassette  (OriGene)
94
OriGene non effective 29 mer scrambled shrna cassette
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
Non Effective 29 Mer Scrambled Shrna Cassette, supplied by OriGene, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/non effective 29 mer scrambled shrna cassette/product/OriGene
Average 94 stars, based on 1 article reviews
non effective 29 mer scrambled shrna cassette - by Bioz Stars, 2026-06
94/100 stars
  Buy from Supplier
gene blocks of the dual shrna cassettes containing either shscramble1-shscramble2, shscramble1-shtxnip, or shrbms3-1-shtxnip  (Twist Bioscience)
90
Twist Bioscience gene blocks of the dual shrna cassettes containing either shscramble1-shscramble2, shscramble1-shtxnip, or shrbms3-1-shtxnip
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
Gene Blocks Of The Dual Shrna Cassettes Containing Either Shscramble1 Shscramble2, Shscramble1 Shtxnip, Or Shrbms3 1 Shtxnip, supplied by Twist Bioscience, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gene blocks of the dual shrna cassettes containing either shscramble1-shscramble2, shscramble1-shtxnip, or shrbms3-1-shtxnip/product/Twist Bioscience
Average 90 stars, based on 1 article reviews
gene blocks of the dual shrna cassettes containing either shscramble1-shscramble2, shscramble1-shtxnip, or shrbms3-1-shtxnip - by Bioz Stars, 2026-06
90/100 stars
  Buy from Supplier
gfp shrna cassette  (Addgene inc)
95
Addgene inc gfp shrna cassette
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
Gfp Shrna Cassette, supplied by Addgene inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gfp shrna cassette/product/Addgene inc
Average 95 stars, based on 1 article reviews
gfp shrna cassette - by Bioz Stars, 2026-06
95/100 stars
  Buy from Supplier
control scrambled shrna cassette  (OriGene)
94
OriGene control scrambled shrna cassette
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
Control Scrambled Shrna Cassette, supplied by OriGene, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/control scrambled shrna cassette/product/OriGene
Average 94 stars, based on 1 article reviews
control scrambled shrna cassette - by Bioz Stars, 2026-06
94/100 stars
  Buy from Supplier
mer non effective scrambled shrna cassette  (OriGene)
93
OriGene mer non effective scrambled shrna cassette
Bioinformatic analysis of <t>LAIR1</t> expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.
Mer Non Effective Scrambled Shrna Cassette, supplied by OriGene, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mer non effective scrambled shrna cassette/product/OriGene
Average 93 stars, based on 1 article reviews
mer non effective scrambled shrna cassette - by Bioz Stars, 2026-06
93/100 stars
  Buy from Supplier

Image Search Results


Bioinformatic analysis of LAIR1 expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.

Journal: Translational Cancer Research

Article Title: Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis

doi: 10.21037/tcr-2026-1-0136

Figure Lengend Snippet: Bioinformatic analysis of LAIR1 expression in pan-cancer and its prognostic value in GC. (A) LAIR1 expression across cancers from TIMER2. (B-D) Poor prognosis associated with high LAIR1 expression (probe 208071_s_at) in GC: (B) OS, (C) FPS, (D) PPS. (E-G) Poor prognosis associated with high LAIR1 expression (probe 210644_s_at) in GC: (E) OS, (F) FPS, (G) PPS. *, P<0.05; ***, P<0.001. CI, confidence interval; FPS, first progression survival; GC, gastric cancer; HR, hazard ratio; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; OS, overall survival; PPS, post-progression survival; TPM, transcripts per million.

Article Snippet: To modulate LAIR1 expression, lentiviral vectors carrying short hairpin RNA targeting LAIR1 (shLAIR1), a nontargeting scrambled negative control short hairpin RNA (shNC), or a LAIR1 overexpression cassette were constructed and supplied by Shanghai GeneChem Co., Ltd. (Shanghai, China).

Techniques: Expressing

Expression and prognostic analysis of LAIR1 in GC. (A) Representative images showing low LAIR1 expression in normal gastric tissue and high expression in GC tissue. Negative staining (IHC scores 1–2), weak staining (IHC scores 3–4), moderate staining (IHC scores 6–9), and strong staining (IHC scores 12). (B) OS based on LAIR1 expression status. (C) PFS based on LAIR1 expression status. (D) LAIR1 protein expression in 16 paired GC tissues (N: adjacent normal; T: tumor). (E) LAIR1 mRNA levels in the same 16 paired tissues. ****, P<0.0001. GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GC, gastric cancer; IHC, immunohistochemistry; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; mRNA, messenger RNA; OS, overall survival; PFS, progression-free survival.

Journal: Translational Cancer Research

Article Title: Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis

doi: 10.21037/tcr-2026-1-0136

Figure Lengend Snippet: Expression and prognostic analysis of LAIR1 in GC. (A) Representative images showing low LAIR1 expression in normal gastric tissue and high expression in GC tissue. Negative staining (IHC scores 1–2), weak staining (IHC scores 3–4), moderate staining (IHC scores 6–9), and strong staining (IHC scores 12). (B) OS based on LAIR1 expression status. (C) PFS based on LAIR1 expression status. (D) LAIR1 protein expression in 16 paired GC tissues (N: adjacent normal; T: tumor). (E) LAIR1 mRNA levels in the same 16 paired tissues. ****, P<0.0001. GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GC, gastric cancer; IHC, immunohistochemistry; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; mRNA, messenger RNA; OS, overall survival; PFS, progression-free survival.

Article Snippet: To modulate LAIR1 expression, lentiviral vectors carrying short hairpin RNA targeting LAIR1 (shLAIR1), a nontargeting scrambled negative control short hairpin RNA (shNC), or a LAIR1 overexpression cassette were constructed and supplied by Shanghai GeneChem Co., Ltd. (Shanghai, China).

Techniques: Expressing, Negative Staining, Staining, Immunohistochemistry

LAIR1 expression and its impact on GC cell proliferation. (A) LAIR1 protein levels in various GC cell lines. (B) Statistical analysis of LAIR1 expression across cell lines. (C) Validation of LAIR1 knockdown efficiency via lentivirus in MGC803 cells. (D) Validation of LAIR1 overexpression efficiency in MKN45 cells. (E) Effect of LAIR1 knockdown on cell viability (CCK-8). (F) Effect of LAIR1 overexpression on cell viability (CCK-8). (G) Colony formation after LAIR1 knockdown in MGC803 cells (crystal violet staining). (H) Colony formation after LAIR1 overexpression in MKN45 cells (crystal violet staining). **, P<0.01; ***, P<0.001; ****, P<0.0001; ns, not significant. CCK-8, Cell Counting Kit-8; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GC, gastric cancer; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; sh-1, shLAIR1-1; sh-2, shLAIR1-2; shLAIR1, short hairpin RNA targeting LAIR1.

Journal: Translational Cancer Research

Article Title: Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis

doi: 10.21037/tcr-2026-1-0136

Figure Lengend Snippet: LAIR1 expression and its impact on GC cell proliferation. (A) LAIR1 protein levels in various GC cell lines. (B) Statistical analysis of LAIR1 expression across cell lines. (C) Validation of LAIR1 knockdown efficiency via lentivirus in MGC803 cells. (D) Validation of LAIR1 overexpression efficiency in MKN45 cells. (E) Effect of LAIR1 knockdown on cell viability (CCK-8). (F) Effect of LAIR1 overexpression on cell viability (CCK-8). (G) Colony formation after LAIR1 knockdown in MGC803 cells (crystal violet staining). (H) Colony formation after LAIR1 overexpression in MKN45 cells (crystal violet staining). **, P<0.01; ***, P<0.001; ****, P<0.0001; ns, not significant. CCK-8, Cell Counting Kit-8; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GC, gastric cancer; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; sh-1, shLAIR1-1; sh-2, shLAIR1-2; shLAIR1, short hairpin RNA targeting LAIR1.

Article Snippet: To modulate LAIR1 expression, lentiviral vectors carrying short hairpin RNA targeting LAIR1 (shLAIR1), a nontargeting scrambled negative control short hairpin RNA (shNC), or a LAIR1 overexpression cassette were constructed and supplied by Shanghai GeneChem Co., Ltd. (Shanghai, China).

Techniques: Expressing, Biomarker Discovery, Knockdown, Over Expression, CCK-8 Assay, Staining, Cell Counting, Negative Control, shRNA

Effect of LAIR1 on GC cell migration and invasion. (A) Scratch wound assay in LAIR1-knockdown MGC803 cells. (B) Scratch wound assay in LAIR1-overexpressing MKN45 cells. (C) Transwell invasion assay in LAIR1-knockdown MGC803 cells (crystal violet staining). (D) Transwell invasion assay in LAIR1-overexpressing MKN45 cells (crystal violet staining). ***, P<0.001; ****, P<0.0001. GC, gastric cancer; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; sh-1, shLAIR1-1; sh-2, shLAIR1-2; shLAIR1, short hairpin RNA targeting LAIR1.

Journal: Translational Cancer Research

Article Title: Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis

doi: 10.21037/tcr-2026-1-0136

Figure Lengend Snippet: Effect of LAIR1 on GC cell migration and invasion. (A) Scratch wound assay in LAIR1-knockdown MGC803 cells. (B) Scratch wound assay in LAIR1-overexpressing MKN45 cells. (C) Transwell invasion assay in LAIR1-knockdown MGC803 cells (crystal violet staining). (D) Transwell invasion assay in LAIR1-overexpressing MKN45 cells (crystal violet staining). ***, P<0.001; ****, P<0.0001. GC, gastric cancer; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; sh-1, shLAIR1-1; sh-2, shLAIR1-2; shLAIR1, short hairpin RNA targeting LAIR1.

Article Snippet: To modulate LAIR1 expression, lentiviral vectors carrying short hairpin RNA targeting LAIR1 (shLAIR1), a nontargeting scrambled negative control short hairpin RNA (shNC), or a LAIR1 overexpression cassette were constructed and supplied by Shanghai GeneChem Co., Ltd. (Shanghai, China).

Techniques: Migration, Scratch Wound Assay Assay, Knockdown, Transwell Invasion Assay, Staining, Negative Control, shRNA

Effect of LAIR1 knockdown on subcutaneous tumor growth in nude mice. (A) Tumorigenesis in nude mice following LAIR1 downregulation. (B,C) Tumor progression: significant differences in subcutaneous tumor growth curves (B) and final tumor weights (C). (D) IHC scores for LAIR1 and Ki-67. (E) Representative IHC images for LAIR1. (F) Representative IHC images for Ki-67. **, P<0.01; ****, P<0.0001. IHC, immunohistochemistry; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; shLAIR1, short hairpin RNA targeting LAIR1.

Journal: Translational Cancer Research

Article Title: Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis

doi: 10.21037/tcr-2026-1-0136

Figure Lengend Snippet: Effect of LAIR1 knockdown on subcutaneous tumor growth in nude mice. (A) Tumorigenesis in nude mice following LAIR1 downregulation. (B,C) Tumor progression: significant differences in subcutaneous tumor growth curves (B) and final tumor weights (C). (D) IHC scores for LAIR1 and Ki-67. (E) Representative IHC images for LAIR1. (F) Representative IHC images for Ki-67. **, P<0.01; ****, P<0.0001. IHC, immunohistochemistry; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; shLAIR1, short hairpin RNA targeting LAIR1.

Article Snippet: To modulate LAIR1 expression, lentiviral vectors carrying short hairpin RNA targeting LAIR1 (shLAIR1), a nontargeting scrambled negative control short hairpin RNA (shNC), or a LAIR1 overexpression cassette were constructed and supplied by Shanghai GeneChem Co., Ltd. (Shanghai, China).

Techniques: Knockdown, Immunohistochemistry, Negative Control, shRNA

Effect of LAIR1 knockdown on peritoneal metastasis in nude mice. (A) Representative images of peritoneal metastatic nodules. (B) The number of nodules in the peritoneal metastases of nude mice exhibited significant variations. (C) IHC scores for LAIR1, Snail1, N-cadherin, and E-cadherin. (D-G) Representative IHC images for LAIR1 (D), Snail1 (E), N-cadherin (F), and E-cadherin (G). *, P<0.05; **, P<0.01; ****, P<0.0001. IHC, immunohistochemistry; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; shLAIR1, short hairpin RNA targeting LAIR1.

Journal: Translational Cancer Research

Article Title: Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis

doi: 10.21037/tcr-2026-1-0136

Figure Lengend Snippet: Effect of LAIR1 knockdown on peritoneal metastasis in nude mice. (A) Representative images of peritoneal metastatic nodules. (B) The number of nodules in the peritoneal metastases of nude mice exhibited significant variations. (C) IHC scores for LAIR1, Snail1, N-cadherin, and E-cadherin. (D-G) Representative IHC images for LAIR1 (D), Snail1 (E), N-cadherin (F), and E-cadherin (G). *, P<0.05; **, P<0.01; ****, P<0.0001. IHC, immunohistochemistry; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; shLAIR1, short hairpin RNA targeting LAIR1.

Article Snippet: To modulate LAIR1 expression, lentiviral vectors carrying short hairpin RNA targeting LAIR1 (shLAIR1), a nontargeting scrambled negative control short hairpin RNA (shNC), or a LAIR1 overexpression cassette were constructed and supplied by Shanghai GeneChem Co., Ltd. (Shanghai, China).

Techniques: Knockdown, Immunohistochemistry, Negative Control, shRNA

Effect of LAIR1 knockdown on lung and lymph node metastasis in nude mice. (A) Gross view of lung metastasis. (B) Lung metastatic nodules visualized by H&E staining. (C) Quantitative analysis of metastatic lung nodules. (D) Gross view of lymph node metastasis. (E) Quantitative analysis of metastatic lymph nodes. **, P<0.01; ****, P<0.0001. H&E, hematoxylin-eosin; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; shLAIR1, short hairpin RNA targeting LAIR1.

Journal: Translational Cancer Research

Article Title: Unveiling LAIR1: a prognostic biomarker associated with gastric cancer progression and metastasis

doi: 10.21037/tcr-2026-1-0136

Figure Lengend Snippet: Effect of LAIR1 knockdown on lung and lymph node metastasis in nude mice. (A) Gross view of lung metastasis. (B) Lung metastatic nodules visualized by H&E staining. (C) Quantitative analysis of metastatic lung nodules. (D) Gross view of lymph node metastasis. (E) Quantitative analysis of metastatic lymph nodes. **, P<0.01; ****, P<0.0001. H&E, hematoxylin-eosin; LAIR1, leukocyte-associated immunoglobulin-like receptor 1; NC, negative control; shLAIR1, short hairpin RNA targeting LAIR1.

Article Snippet: To modulate LAIR1 expression, lentiviral vectors carrying short hairpin RNA targeting LAIR1 (shLAIR1), a nontargeting scrambled negative control short hairpin RNA (shNC), or a LAIR1 overexpression cassette were constructed and supplied by Shanghai GeneChem Co., Ltd. (Shanghai, China).

Techniques: Knockdown, Staining, Negative Control, shRNA